Showing posts with label HEALTH. Show all posts
Showing posts with label HEALTH. Show all posts

Florida just announced that mosquitoes are probably transmitting Zika in the US





The State of Florida has confirmed four cases of Zika infection in a small Miami neighbourhood, and announced over the weekend that they were likely caused by mosquito bites.

This makes Florida the first state in the continental United States to experience a local transmission of the virus, and officials are urging locals to get tested.

"The bottom line is that Zika is now here," Tom Frieden, director of the Centres for Disease Control and Prevention (CDC), announced in a press briefing.

"Florida has become the first state in our country to have a local transmission of the Zika virus," the governor of Florida, Rick Scott, said at a separate press conference in Orlando.

So how did this all happen? Last week, officials confirmed that four unexplained Zika cases had cropped up in Florida’s Miami-Dade and Broward counties.


The three men and one woman infected with the virus had not travelled to Zika-affected countries and brought back an infection, nor had they contracted the virus sexually, leaving experts to state that by far the most likely explanation was that they’d been infected by local Aedes aegypti mosquitoes.

To be clear, all we have to go on right now is circumstantial evidence, and so far, no local mosquitos have been found to be carrying Zika. But as Frieden told Rita Rubin from Forbes, this isn't exactly a surprise, as finding the individual culprits is like "finding a needle in a haystack".

The CDC is now advising that everyone in the area - especially pregnant women or women planning to get pregnant - to avoid mosquito bites and get tested. Though the virus only produces fairly mild symptoms, such as a fever or a rash, in most adults, in pregnant women, it can cause very serious defects in childrenborn with microcephaly.

"All the evidence we have seen indicates that this is mosquito-borne transmission that occurred several weeks ago in several blocks in Miami,"Frieden said in a CDC press release.

"We continue to recommend that everyone in areas where Aedes aegyptimosquitoes are present - and especially pregnant women - take steps to avoid mosquito bites. We will continue to support Florida’s efforts to investigate and respond to Zika and will reassess the situation and our recommendations on a daily basis."

The good news is all four cases appear to have been transmitted in an area of just 1 square mile (2.6 square kilometres) just north of downtown Miami.

As George Dvorsky reports for Gizmodo, the exact location is within Northwest 5th Avenue to the west, US 1 to the east, Northwest/Northeast 38th Street to the north and Northwest/Northeast 20th Street to the south.

The other good news is that the CDC says that even if they do manage to confirm that local mosquitos are transmitting the virus, it’s unlikely this will turn into a full-blown epidemic, the likes of which have been seen in several areas of Latin American and the Caribbean.

"Our environment isn’t conducive to those mosquitoes," Frieden said in the press briefing, "partly because people use screens and air-conditioning. For whatever the reason, we don't generally see clusters.

Frieden added that Aedes aegypti mosquitoes can only travel up to 150 metres (about 500 feet) in their lifetime, making it very difficult for them to make it out of the affected area.

"We do not believe there will be ongoing transmission," Florida Surgeon General, Celeste Philip, told the press in Orlando.

If you're in the affected area, expect to see a temporary ban on blood donationsfor some time, and you just might have health officials knocking on your doorwith free mozzie repellents. Stay safe, everyone.

By sciencealert
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Scientists have found a new way to stop skin damage and ageing from the Sun



Traditional sunscreen works by reflecting harmful ultraviolet A (UVA) radiation away from your skin, but a new compound does something even better - it guards your skin cells from the effects of the sun from the inside out.

Offering protection inside the cell where the greatest damage from UVA occurs, this compound is said to offer "unprecedented protection" against skin cancer, and the effects of photoageing, such as sags, wrinkles, and sunspots.

Dubbed the mitoiron claw, the compound clings to the insides of cells, and prevents the kind of iron leakage that's triggered by UVA exposure. If severe enough, this iron leakage can ultimately leads to cell destruction.

To understand why loose iron is such a problem, you need to understand how UVA affects cells. Radiation from the Sun unlocks free radicals - highly active oxygen molecules - in the skin, which then cause damage to DNA, cell membranes, and proteins.

At the same time, it also releases iron from the cell's mitochondria, which depletes the cell's energy supply and causes the cells to produce more free radicals. In other words, UVA causes cells to be killed off, and this can eventually lead to skin cancer.


It also causes skin to sag, wrinkle, and age, as you might have noticed if you spent a lot of time basking in the sunshine as a kid.

To combat this, researchers from the University of Bath and King's College London in the UK developed the mitoiron claw, which is a type of chelator - a compound that binds to an iron atom. This allows it to target iron that's loose in the mitochondria of the cell and prevent the release of extra free radicals.

"The role of iron-mediated damage induced upon exposure of skin cells to UVA has been underestimated for many years," said one of the team, Charareh Pourzand from the University of Bath. "For efficient protection against UVA-induced iron damage of skin strong chelators are needed, but until now these risked toxic effects caused by non-targeted iron starvation of cells."

While the new substance focusses on UVA, protection is also needed against ultraviolet B (UVB) rays, short wave radiation that is even more of a risk when it comes to skin cancer.

The next step is to get the compound into existing sprays and creams with UVB protection. Although the initial mitoiron claw results have been promising, they've only been tested on human cells grown in a lab so far, but the scientists estimate their compound could make it to our sunscreen in three to four years.

"The current sunscreens are not bad, but they can certainly be improved," pharmacologist and lead researcher, Olivier Reelfs from the University of Bath, told Kelsey Kennedy at Quartz.


By sciencealert
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